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The Concept Of 'overactive Bladder' Serves Better Commercial Rather Than Patient Interests

"The overactive bladder syndrome has become an accepted way to simplify a complex array of symptoms and leads people to believe that an overactive bladder is an independent disease in itself. However, the truth is not as simple as this, as there are usually several factors at work explaining the sym... (original story)

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Pelvic floor muscle training for urgency urinary incontinence in women: a systematic review

The objective of this study is to evaluate the effectiveness of existing physiotherapy modalities for the treatment of urge urinary incontinence (UUI). A systematic review was performed for primary studies of physiotherapy techniques for UUI published in English between 1996 and August 2010 in maj... (original story)

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Are Costs for Robotic Assisted Sacrocolpopexy Lower Than Those for Open Sacrocolpopexy?

In this issue of The Journal Elliott et al (page 638) from Stanford, California present a cost-minimization analysis of data about robotic assisted sacrocolpopexy (RASC) and open sacrocolpopexy (OSC) performed at 1 institution in a 5-year period. A cost-minimization analysis can measure break-even (... (original story)

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New Software For Analyzing Digital Pathology Separates Malignancy From Background Tissue In Bladder Cancer Test Case

As tissue slides are more routinely digitized to aid interpretation, a software program whose design was led by the University of Michigan Health System is proving its utility. In a new study, a program known as Spatially Invariant Vector Quantization (SIVQ) was able to separate malignancy from back... (original story)

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Acute Kidney Injury In Emergency Cases - Using Biomarkers

A study published online in the Journal of the American College of Cardiology reports that researchers have discovered a new approach for diagnosing acute kidney injury (AKI), which has severe consequences with a 25 to 80% risk of in-hospital death, that allows emergency departments to identify high... (original story)

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Tapping The Body's Own Defenses, Researchers Look To Cutting-Edge Gene Therapy For Bladder Cancer

Bladder cancer, most frequently caused by smoking and exposure to carcinogens in the workplace, is one of the top 10 most common forms of cancer in men and women in the U.S. More than 70 percent of bladder cancers are diagnosed in stage T1 or less and have not invaded the muscle layer. At these earl... (original story)

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Is it possible to model the risk of malignancy of focal abnormalities found at prostate multiparametric MRI?

Conclusions  A simple combination of signal abnormalities of individual MR sequences can significantly stratify the risk of malignancy of FAs, holding promise of a more standardised interpretation of MRI by readers with varying experience. Key Points   • Using mult... (original story)

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Complex morphology and functional dynamics of vital murine intestinal mucosa revealed by autofluorescence 2-photon microscopy

Abstract  The mucosa of the gastrointestinal tract is a dynamic tissue composed of numerous cell types with complex cellular functions. Study of the vital intestinal mucosa has been hampered by lack of suitable model systems. We here present a novel animal model that enables highly resol... (original story)

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Severe acute hypophosphatemia during renal replacement therapy adversely affects outcome of critically ill patients with acute kidney injury

Conclusions  This multicenter study indicates for the first time that hypophosphatemia during IHD adversely affects short- and long-term outcome of critically-ill patients with AKI. The clinical consequences of the acute hypophosphatemic syndrome may be prevented by PS. Content ... (original story)

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Which clinical risk factors determine a pathological urodynamic evaluation in patients with multiple sclerosis? an analysis of 100 prospective cases

Conclusions  The urodynamic investigation at hand showed urinary tract dysfunction in 78 of 100 MS patients with lower urinary tract symptoms (LUTS). The long latency between the occurrence of MS and/or the beginning of LUTS and the first neuro-urological evaluation indicates a deficit i... (original story)

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